Scripps NeuroAIDS Preclinical Studies (SNAPS)

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2004 2003 2002 2000-2001

Scripps NeuroAIDS Preclinical Studies (SNAPS) Center
Supported by the National Institute for Mental Health
P30 MH62261
Publications 2003

  1. Bale, T.L., K.R. Anderson, A.J. Roberts, K.F. Lee, T.R. Nagy, and W.W. Vale, Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold. Endocrinology, 2003. 144:2580-7.
  2. Barr, M.C., S. Huitron-Resendiz, M. Sanchez-Alavez, S.J. Henriksen, and T.R. Phillips, Escalating morphine exposures followed by withdrawal in feline immunodeficiency virus-infected cats: a model for HIV infection in chronic opiate abusers. Drug Alcohol Depend, 2003. 72:141-9.
  3. Bobardt, M.D., A.C. Saphire, H.C. Hung, X. Yu, B. Van der Schueren, Z. Zhang, G. David, and P.A. Gallay, Syndecan captures, protects, and transmits HIV to T lymphocytes. Immunity, 2003. 18:27-39.
  4. Brik, A., J. Muldoon, Y.C. Lin, J.H. Elder, D.S. Goodsell, A.J. Olson, V.V. Fokin, K.B. Sharpless, and C.H. Wong, Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. Chembiochem, 2003. 4:1246-8.
  5. Carrasco, J., M. Penkowa, M. Giralt, J. Camats, A. Molinero, I.L. Campbell, R.D. Palmiter, and J. Hidalgo, Role of metallothionein-III following central nervous system damage. Neurobiol Dis, 2003. 13:22-36.
  6. Finn, D.A., A.J. Roberts, S. Long, M. Tanchuck, and T.J. Phillips, Neurosteroid consumption has anxiolytic effects in mice. Pharmacol Biochem Behav, 2003. 76:451-62.
  7. Holmberg, K., S. Mariathasan, T. Ohteki, P.S. Ohashi, and N.R. Gascoigne, TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol, 2003. 171:2427-34.
  8. Kayali, A.G., K. Van Gunst, I.L. Campbell, A. Stotland, M. Kritzik, G. Liu, M. Flodstrom-Tullberg, Y.Q. Zhang, and N. Sarvetnick, The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol, 2003. 163:859-69.
  9. Lewicki, H., A. Tishon, D. Homann, H. Mazarguil, F. Laval, V.C. Asensio, I.L. Campbell, S. DeArmond, B. Coon, C. Teng, J.E. Gairin, and M.B. Oldstone, T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies. J Virol, 2003. 77:3799-808.
  10. Lin, Y.C., Z. Beck, G.M. Morris, A.J. Olson, and J.H. Elder, Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases. J Virol, 2003. 77:6589-600.
  11. Mak, C.C., A. Brik, D.L. Lerner, J.H. Elder, G.M. Morris, A.J. Olson, and C.H. Wong, Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases. Bioorg Med Chem, 2003. 11:2025-40.
  12. Marcondes, M.C., C.A. Phillipson, and H.S. Fox, Distinct clonal repertoire of brain CD8+ cells in simian immunodeficiency virus infection. Aids, 2003. 17:1605-11.
  13. Milner, R. and I.L. Campbell, The extracellular matrix and cytokines regulate microglial integrin expression and activation. J Immunol, 2003. 170:3850-8.
  14. Molinero, A., M. Penkowa, J. Hernandez, J. Camats, M. Giralt, N. Lago, J. Carrasco, I.L. Campbell, and J. Hidalgo, Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6. J Neuropathol Exp Neurol, 2003. 62:315-28.
  15. Penkowa, M., M. Giralt, N. Lago, J. Camats, J. Carrasco, J. Hernandez, A. Molinero, I.L. Campbell, and J. Hidalgo, Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Exp Neurol, 2003. 181:130-48.
  16. Penkowa, M., J. Camats, H. Hadberg, A. Quintana, S. Rojas, M. Giralt, A. Molinero, I.L. Campbell, and J. Hidalgo, Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. J Neurosci Res, 2003. 73:481-96.
  17. Penkowa, M., J. Camats, M. Giralt, A. Molinero, J. Hernandez, J. Carrasco, I.L. Campbell, and J. Hidalgo, Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia, 2003. 42:287-306.
  18. Qiu, Z. and D.L. Gruol, Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons. J Neuroimmunol, 2003. 139:51-7.
  19. Roberts, E.S., M.A. Zandonatti, D.D. Watry, L.J. Madden, S.J. Henriksen, M.A. Taffe, and H.S. Fox, Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol, 2003. 162:2041-57.
  20. Samland, H., S. Huitron-Resendiz, E. Masliah, J. Criado, S.J. Henriksen, and I.L. Campbell, Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J Neurosci Res, 2003. 73:176-87.
  21. Simmons, G., J.D. Reeves, C.C. Grogan, L.H. Vandenberghe, F. Baribaud, J.C. Whitbeck, E. Burke, M.J. Buchmeier, E.J. Soilleux, J.L. Riley, R.W. Doms, P. Bates, and S. Pohlmann, DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells. Virology, 2003. 305:115-23.
  22. Taffe, M.A., S. Huitron-Resendiz, R. Schroeder, L.H. Parsons, S.J. Henriksen, and L.H. Gold, MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys. Pharmacol Biochem Behav, 2003. 76:141-52.
  23. Valdez, G.R., E.P. Zorrilla, A.J. Roberts, and G.F. Koob, Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol, 2003. 29:55-60.
  24. Wang, J., N. Pham-Mitchell, C. Schindler, and I.L. Campbell, Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain. J Clin Invest, 2003. 112:535-43.
  25. Zwick, M.B., P.W. Parren, E.O. Saphire, S. Church, M. Wang, J.K. Scott, P.E. Dawson, I.A. Wilson, and D.R. Burton, Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. J Virol, 2003. 77:5863-76.